SUPPOSITORIES
Vijayaraj Marham
suppository users report powerful, localized, non-psychotropic effects for a range of middle and lower body afflictions. The rectum also contains a number of key veins that deliver blood to the entire body, but it doesn’t appear that suppositories facilitate cannabinoid absorption into the bloodstream.Even if they are only effective locally rather than systemically, suppositories may offer a viable alternative to patients suffering from conditions that render them unable to ingest their prescriptions orally. Issues with palatability, severe nausea or vomiting, compromised esophageal or gastrointestinal tracts, and a range of other symptoms can make oral administration an impossibility for many patients. The suppository is formulated using ingredients Camphor , Frankincense essential oil , Curcuma Longa oil , Beeswax ( small indica bees wax ) Garcinia India and plant waxes, coconut oil , sesame oil and Raw vijaya extract 1:2 .
Vijayaraj Marham ( Rectal Suppositories)
Product is developd based on the research conducted by group of eminent scientists Mahmoud A. ElSohlya , Waseem Gula, Larry A. Walkera, via article ( Tolerability of Δ9-THC-Hemisuccinate in a Suppository Formulation as an Alternative to Capsules ) .Study finds out oral absorption is slow and erratic, and the “first-pass” metabolic effect is high, so that when administered orally, there is a variable peak in Δ9 -THC in plasma ranging from 45 min to a few hours, and an overall systemic bioavailability of about 10% . In addition to these pharmacokinetic considerations, the use of capsules in many of these indications can be limited by nausea, vomiting, or difficulty in swallowing. Alternatives for systemic delivery of CBD + THC based formulations via suppository administration is one of the methodologies .
Product is developd based on the research conducted by group of eminent scientists Mahmoud A. ElSohlya , Waseem Gula, Larry A. Walkera, via article ( Tolerability of Δ9-THC-Hemisuccinate in a Suppository Formulation as an Alternative to Capsules ) .Study finds out oral absorption is slow and erratic, and the “first-pass” metabolic effect is high, so that when administered orally, there is a variable peak in Δ9 -THC in plasma ranging from 45 min to a few hours, and an overall systemic bioavailability of about 10% . In addition to these pharmacokinetic considerations, the use of capsules in many of these indications can be limited by nausea, vomiting, or difficulty in swallowing. Alternatives for systemic delivery of CBD + THC based formulations via suppository administration is one of the methodologies .