SUPPLEMENTS
TEST
Lion's Mane Mushroom extract -50mg
Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system. Hericenones and erinacines isolated from the medicinal mushroom Hericium erinaceus can induce NGF synthesis in nerve cells. In this study, we evaluated the synergistic interaction between H. erinaceus aqueous extract and exogenous NGF on the neurite outgrowth stimulation of neuroblastoma-glioma cell NG108-15. The neuroprotective effect of the mushroom extract toward oxidative stress was also studied. Aqueous extract of H. erinaceus was shown to be non-cytotoxic to human lung fibroblast MRC-5 and NG108-15 cells. The combination of 10 ng/mL NGF with 1 μg/mL mushroom extract yielded the highest percentage increase of 60.6% neurite outgrowth. The extract contained neuroactive compounds that induced the secretion of extracellular NGF in NG108-15 cells, thereby promoting neurite outgrowth activity. However, the H. erinaceus extract failed to protect NG108-15 cells subjected to oxidative stress when applied in pre-treatment and co-treatment modes. In conclusion, the aqueous extract of H. erinaceus contained neuroactive compounds which induced NGF-synthesis and promoted neurite outgrowth in NG108-15 cells. The extract also enhanced the neurite outgrowth stimulation activity of NGF when applied in combination. The aqueous preparation of H. erinaceus had neurotrophic but not neuroprotective activities.
Rhus parviflora extract -50mg
Rhus parviflora extract (50% Fisetin) is flavonoid found in many fruits and vegetables, including strawberries, apples, persimmon, grapes, onions, and cucumbers. As seen in the diagram below, strawberries contain much more fisetin than other fruits and vegetables. Aging expert and professor Paul D. Robbins and a team of scientists examined fisetin's effects on aging and longevity in rodents. They found that mice exposed to fisetin lived 10% longer and experienced fewer age-related issues than the control group, even at an older age. These promising results drove the Mayo Clinic to sponsor a clinical trial examining the direct effects of fisetin supplementation on age-related dysfunction in humans.Another prominent scientist Dr. Maher, Ph.D., also discovered impressive findings, especially fisetin's impact on the brain. Her research in mice illustrated fisetin’s neuroprotective and memory-enhancing properties. One particular study included mice with Huntington's Disease (HD), an inherited disease that damages and destroys neurons in the brain. Mice with HD that were fed fisetin experienced a delayed onset of motor defects and lived 30% longer. Fisetin's unique characteristics, including its ability to act as a senolytic, antioxidant, and mimic calorie restriction, potentially explain these findings.
Bacopa monnieri extract -100mg
Research suggests that Bacopa monnieri may help enhance brain function. For example, one study in mice showed that supplementing with Bacopa monnieri improved their spatial learning and ability to retain information The same study also found that it increased dendritic length and branching. Dendrites are parts of nerve cells in the brain that are closely linked to learning and memory Additionally, a 12-week study in 46 healthy adults observed that taking 300 mg of Bacopa monnieri daily significantly improved the speed of processing visual information, learning rate, and memory, compared with the placebo treatment Another 12-week study in 60 older adults found that taking either 300 mg or 600 mg of Bacopa monnieri extract daily improved memory, attention, and the ability to process information, compared with the placebo treatment